Periodontal Disease and COVID-19

Authors

Zhaozhao Chen DDS, MS, PhD, Department of Periodontics University of Michigan School of DentistryFollow
Laurie K. McCauley DDS, MS, PhD, University of Michigan School of DentistryFollow
Purnima S. Kumar BDS, MS, PhD, Department of Periodontics University of Michigan School of DentistryFollow
Hom-Lay Wang DDS, MS, PhD, Department of Periodontics University of Michigan School of DentistryFollow

Abstract

As the gateway to the respiratory system, the oral cavity can play an essential role in SARS-CoV-2 invasion and transmission. Besides high expression of angiotensin‐converting enzyme 2 (ACE2), the oral cavity can harbor viral particles in saliva, gingival crevicular fluid, and the periodontal pocket. Microbial and inflammatory associations closely link periodontitis and COVID-19. In this review, we summarize the possible oral manifestations of COVID‐19, its association with periodontal diseases, the plausible underlying mechanisms of microbial and inflammatory crosstalk between COVID‐19 and periodontal diseases, and mitigation protocols during periodontal treatment.

Recommended Citation

Chen, Zhaozhao DDS, MS, PhD; McCauley, Laurie K. DDS, MS, PhD; Kumar, Purnima S. BDS, MS, PhD; and Wang, Hom-Lay DDS, MS, PhD (2022) "Periodontal Disease and COVID-19," The Journal of the Michigan Dental Association: Vol. 104: No. 5, Article 8.
Available at: https://commons.ada.org/journalmichigandentalassociation/vol104/iss5/8