Published Article
Summary of the evidence on the safety, efficacy, and effectiveness of human papillomavirus vaccines: Umbrella review of systematic reviews
Original Publisher or Platform
Journal of the American Dental Association
Original Article Link
https://doi.org/10.1016/j.adaj.2019.10.010
Publication Date
4-2020
Abstract
This search strategy was constructed to support the research for the peer reviewed article listed above. Full article abstract:
Background
This objective of this umbrella review was to summarize the evidence on safety, efficacy, and effectiveness of human papillomavirus (HPV) vaccines in the general population.
Methods
The authors conducted a literature search and selected systematic reviews if they were published from January 2006 through November 2018, included randomized controlled trials or observational studies, related to the general population, and evaluated HPV vaccine-related clinical outcomes. The authors independently and in duplicate screened literature, extracted data, and appraised reviews using AMSTAR 2, a critical appraisal tool for systematic reviews.
Results
The authors selected 30 systematic reviews that included male and female participants aged 9 through 76 years from multiple countries. Reviews evaluated postvaccine seroconversion, HPV infection rates, precancerous or benign lesions, and adverse events; none of the researchers reported on oral or oropharyngeal lesions. Results from the reviews showed that, compared with those who received a placebo or non-HPV-type vaccine, HPV-vaccinated participants had statistically significantly higher rates of seroconversion and local adverse events, statistically significantly lower rates of HPV infection and condylomata lesions, and decreased rates of HPV-related precancerous lesions, which did not always attain statistical significance.
Conclusions
Systematic reviews have found evidence that the available HPV vaccines are safe, effective, and efficacious against vaccine-type HPV infection and HPV-associated cellular changes, including precancerous and benign lesions.
Practical Implications
Dentists may use this resource to better understand the literature on the potential harms and benefits of HPV vaccination.
PICO(T) or Research Question
Condition or domain being studied
Human papillomavirus
Population
General population. No restriction by gender. Reports that only apply to those with a specific health condition will not be included.
Intervention(s) or exposure(s)
Human papillomavirus vaccines, any dose or type.
Comparator(s) or control(s)
Did not receive an HPV vaccine
Context
This umbrella review is intended to provide background for those considering raising awareness of the HPV vaccine among the general public.
Search Type
Umbrella Review
Databases included
PubMed or PubMed subsidiary, Embase, CINAHL, Cochrane
Registered Protocol Link
https://www.crd.york.ac.uk/PROSPERO/view/CRD42019118971
Acknowledgments
The full article was authored by: Alessandro Villa, DDS, PhD, MPH; Lauren L. Patton, DDS; Anna R. Giuliano, PhD; Cameron G. Estrich, MPH; Sarah C. Pahlke, MSc; Kelly K. O’Brien, MLIS; Ruth D. Lipman, PhD; Marcelo W.B. Araujo, DDS, PhD, MS
Recommended Citation
O'Brien, Kelly K. MSLIS, "Expert search for "Summary of the evidence on the safety, efficacy, and effectiveness of human papillomavirus vaccines"" (2020).
Original article at https://doi.org/10.1016/j.adaj.2019.10.010.
Expert Search Strategies. 1.
https://commons.ada.org/expertsearches/1