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Keywords

Toothbrushing, Toothpaste, Peanut allergy, Desensitization, Immunotherapy

Abstract

Peanut allergies pose significant health risks globally, with an increasing prevalence observed over the past two decades. Accidental exposures to peanuts can lead to severe allergic reactions, including anaphylaxis, prompting the exploration of innovative therapeutic approaches to mitigate these risks. This literature review examines the potential use of peanut proteins embedded within toothpaste formulations as a novel avenue for inducing tolerance in individuals with peanut allergies. It includes recent studies and clinical trials in oral immunotherapy, focusing on mechanisms of action, safety profiles and long-term outcomes associated with controlled allergen exposure. Key findings suggest that oral mucosal therapy, particularly sublingual immunotherapy, may offer a safer alternative to traditional oral ingestion methods, with promising results in desensitization and sustained tolerance induction. Furthermore, the review highlights the broader implications of peanut allergy desensitization, including improved quality of life and the potential application of similar approaches for other allergens. While further research is needed to optimize this therapeutic modality, toothpaste-based immunotherapy presents a promising avenue for enhancing patient safety and promoting lasting tolerance in individuals with peanut allergies.

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